Glucosamine - Herb Interactions, Side Effects and Precautions of Use
Common Trade Names
Multi-ingredient preparations: Arth-X Plus, Bioflex, Enhanced Glucosamine Sulfate, F1exi-Factors, Glucosamine Complex, Glucosamine Mega, Joint Factors, Nutri-Joint, Ultra Maximum Strength Glucosamine Sulfate
Various molecular forms of glucosamine are available, including chlorhydrate, D-glucosamine, hydrochloride, N-acetyl, sulfate, and with potassium chloride added. The preferred form appears to be glucosamine sulfate.
Capsules: 250 mg, 375 mg, 500 mg, 600 mg, 1,000 mg
Tablets: 63 mg, 87 mg, 375 mg, 500 mg, 600 mg, 750 mg
Glucosamine is a natural substance found in mucopolysaccharides, mucoproteins, and chitin. Glucosamine sulfate is synthetically manufactured.
Glucosamine sulfate is the sulfate salt of 2-amino-2-deoXY-D-chitin glucopyranose.
Glucosamine is believed to stimulate production of cartilage components and allow rebuilding of damaged cartilage. Early in vitro studies found that culture-derived fibroblast increased mucopolysaccharide and collagen synthesis when glucosamine was added .
In vivo and in vitro studies conducted in rats demonstrated that glucosamine can severely impair insulin secretion and beta-cell secretory dysfunction similar to that observed in patients with type 2 diabetes mellitus .
Uses for Glucosamine
Glucosamine is thought to be useful as an antarthritic in patients with osteoarthritis or other joint disorders.
The dose used in several clinical trials was 500 mg P.O. t.i.d.
Other dosages were based on patient weight: If weight is below 120 lb (54 kg), 1,000 mg of glucosamine plus 800 mg of chondroitin sulfates; between 120 and 200 lb (91 kg), 1,500 mg of glucosamine plus 1,200 mg of chondroitin sulfates; and above 200 lb, 2,000 mg of glucosamine plus 1,600 mg of chondroitin sulfates.
CNS: drowsiness, headache.
GI: abdominal pain, constipation, diarrhea, epigastic discomfort, heartburn, nausea.
Contraindications And Precautions
Avoid using glucosamine in patients who are hypersensitive to glucosamine or any of its components, in pregnant or breast-feeding women, and in children; effects are unknown.
Interactions and Side Effects
The herb glucosamine has none reported side effects, so you can start using it without any problem.
Several trials have demonstrated that glucosamine sulfate can improve symptoms of osteoarthritis. Many contain major study design flaws and critical problems with data analysis, placing their conclusions in jeopardy. Furthermore, all trials do not support the efficacy of glucosamine over placebo. There are few large, controlled clinical trials evaluating the use of glucosamine with chondroitin sulfates that identify positive benefits. Large-scale, long-term, adequately designed, rigorous, controlled studies are needed before glucosamine's role in the treatment of bone and joint disorders can be determined.
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